Potent and selective inactivation of cysteine proteinases with N-peptidyl-O-acyl hydroxylamines
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چکیده
منابع مشابه
Potent and selective inactivation of cysteine proteinases with N-peptidyl-O-acyl hydroxylamines.
A series of N-peptidyl-O-acyl hydroxylamines was synthesized and tested as inactivators of cysteine proteinases. Depending on the structure of the peptidyl residue of the inhibitors, rapid and complete irreversible inactivation of the lysosomal cathepsins, B, L and S, may be achieved. The most effective inhibitors display second-order rate constants of the inactivation in the range 10(5)-10(6) ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1989
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2630861